If Trellix products have communication issues with ePO - On-prem, see below scenarios with KB article details to troubleshoot.
How to troubleshoot the ePO - On-prem data channel — For information about how data channel (DC) works and troubleshoot issues with the data channel, see KB87143.
How to improve your data channel efficiency — For details about how to improve data channel efficiency, particularly in large environments, see KB82022.