Hotfixes include the most current updates to the application. Installing the latest hotfix ensures you have the most up-to-date solution. Hotfixes are cumulative, so if you install Hotfix 4, for example, there is no need to install hotfixes 1-3.
Download the latest hotfix file from the Trellix download site.
Install the hotfix using the instructions in the hotfix release notes available on docs.trellix.com.