You can enable Exploit Prevention policies from ePO - On-prem.
Log on to the ePO - On-prem server as an administrator.
Select Menu | Policy | Policy Catalog, then select Endpoint Secuity Threat Prevention from the Product list.
Select Category as Exploit Prevention.
Open the policy and click Enable Exploit Prevention.
Note
You can enable or disable Exploit Prevention policies using this option.
Click Save.
In the right pane, select Group Details, then click Wake Up Agents.