After configuring your ports for inline mode, setting the TCP/IP parameters, and customizing and applying policy, you will need to download this configuration to the Sensor in order for all of your changes to be active.
Configuration changes, including port configuration, policy, and signature set updates: Devices → <Admin Domain Name> → Devices → <Device_Name> → Deploy Pending Changes
Software updates only: Devices → <Admin Domain Name> → Devices → <Device_Name> → Member Sensors → <HA Pair Node> → Maintenance → Deploy Device Software